Current Issue : January-March Volume : 2011 Issue Number : 1 Articles : 29 Articles
The discussion about a review of pharmacological studies of some medicinal plants as antimicrobial and feed additives potential of medicinal plants. In the United States, food animals are often exposed to antimicrobial compounds to treat or prevent infectious diseases and/or to promote growth. Antibacterial substances are used in considerable amounts as growth promoters in animal husbandry, and carry incalculable risks for human health resulting from the use of particular feed additives. The use of herbs and essential oils may relate to their anti-microbial activity against pathogenic bacteria and parasites....
Gmelina arborea Roxb. (Verbenaceae ) is commonly known as gambhari. Gambhari is one of the herbs mentioned in all ancient scriptures of Ayurveda, as one of the member of brhat pancamulas. Acarya Vagbhata has cited gambhari, one of the members from the group dasamulas, used in vata dosa (vata samsamana). It is traditionally used as diuretic, tonic, aphrodisiac, alternative astringent to the bowels, promote growth of hairs, useful in treatment of anaemia, leprosy, ulcers and vaginal discharge, alopecia, anemia, etc. It is reported to contain alkaloid, glycoside, lignann derivative compound, sesquiterpenoid, flavanoid. Present review summarizes the traditional uses, phytochemistry, reported pharmacological activity and marketed formulation of Gmelina arborea....
Marine source has gained importance in the pharmaceutical field from ancient time onwards as pharmaceutical adjuvant. But now marine environment has proven to be a very rich source of potent compound that has demonstrated significant activities against cancer, inflammation, pain, allergy and human pathogens. But it’s fascinated to know that this unique animal; sponge contains numerous microorganisms that led to the discovery of many antibiotics. Nowadays, researchers have focused on antibacterial activity of marine products since the microorganism became resistant after long use to a synthetic antibiotic. In view of this we have selected marine algae (Ulva reticulata) as the model for antibacterial studies. The bioactive principles were extracted from green algae by continuous hot percolation method using methanol and petroleum ether as solvent for 4 hours. The petroleum ether extracts of green algae showed the presence of various constituents such as carbohydrates, glycosides, proteins, tannins, flavanoids and alkaloids. The spectrum of antibacterial studies were carried out by agar well diffusion technique against B.subtilis MTCC 121, E.coli MTCC 405, S.pyogenes MTCC 442 and S. aureus MTCC 96 and the activity was well compared with standard Ciproflaxacin drug (5µg/disc). The results have shown that all the extracts were effective against E.coli and S. pyogenes when compared to the rest. Hence this preliminary study infers that the potent antibacterial substances can be isolated against various bacterial pathogens....
To evaluate the antihyperglycemic activity of ethanolic extract of Butea monosperma leaf in alloxan induced diabetic rabbit. Healthy albino rabbits, from the Department of Animal house (V.S.S. Medical College, Burla, Orissa), weighing between 1.5 to 2 kg, aged between 6 months to 1 year were taken or this study. The animal under study were isolated and kept in a separate room. Alloxan induced (70 mg/kg i.v.) diabetic rabbit were given ethanolic leaf extract 100,200 and 400 mg/kg , P.O(PER ORAL),n=6} of Butea monosperma or vehicle(5%Tween80 2ml/kg,P.O.) or the standard drug Glyburide(0.5mg/kg.P.O.) for 6weeks. Fasting plasma glucose levels were determined after oral administration of normal and diabetic groups and Fasting plasma glucose, serum triglyceride and total serum cholesterol of diabetic rabbit were observed at 0,4,6 weeks, during highest dose of test drug (400mg).\r\n The ethanolic leaf extract of Butea monosperma leaf extract exerted significant hypoglycemic effect. . In diabetic rabbit reduced hyperglycemia significantly in acute study. In chronic study Butea monosperma leaf extract reduced Fasting plasma glucose significantly at 4 and 6 weeks interval and also lowered the serum triglyceride and total serum cholesterolafter4 to 6 weeks of treatment...
Anti-inflammatory activity of Allium Sativum Linn., on carrageenan induced paw edema in wistar male rats Aqueous, ethanolic and methanolic extracts of Allium Sativum Linn., were investigated for anti-inflammatory activity in carrageenan induced paw edema in wistar male rats, and compared to a positive control drug, Voveran. These extracts were given (ip) in a concentration of 20 and 50 mg/kg b.w. before carrageenan injection. Methanolic extracts of Allium Sativum Linn., with a concentration of 20 mg/kg b.w. and ethanolic extract with a concentration of 50 mg/kg b.w. showed maximum (90.9%) inhibition on carrageenan induced rat paw edema. The effect was significantly (P< 0.05) higher than that of the standard drug Voveran (72.72%). Methanol extract with a concentration of 50 mg/kg b.w. produced 81.81% inhibition, which was also high as compared to the standard drug. Ethanolic extract with a dose of 20 mg/kg b.w and the two doses of aqueous extract produce less percentage of inhibition as compared to the standard drug voveran....
Steroids are distinct group of secondary metabolites that are largely used in pharmaceutical world and exhibit medicinal as well as physiological activities. Steroidal extracts of leaves and seeds of two medicinal plants Pongamia pinnata (L.) Pierre and Vitex negundo Linn. were screened for their antimicrobial activity against some bacterial and fungal strains. Test samples were screened for their antimicrobial activity adopting disc diffusion method against Bacillus cerus, Escherichia coli, Mycobacterium smegmatis, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhimurium, Staphylococcus aureus, S. epidermidis, Candida albicans and Trichoderma viride. Extracts were also assayed for cellular toxicity to fresh human erythrocytes. Maximum activity was observed in steroidal fractions of seeds of V. negundo and found to have no cellular toxicity against erythrocytes. The findings demonstrated that steroids of these plants have significant antimicrobial potential and can act as source of alternative medicines against infectious microorganisms....
Bacterial infections are one of the prominent causes of health problems, physical disabilities and mortalities around the world. Symptoms and complications associated with bacterial infections such as fever, chills, headache, nausea, vomiting and organ failures affect patient’s life severely. Medicinal plants are a rich source of antimicrobial agents and provide a safer and cost effective way of treating bacterial infections. This article describes the antibacterial antimicrobial activity of natural products from medicinal plants. A review of some herbal products for the treatment of bacterial, fungal and viral diseases are provided that highlights the recent technical advancements that have taken place in this area....
Avicennia marina is a mangrove plant and it used coastal village peoples for traditional folk medicine method for varies disease. In general salt tolerance plants have a more antioxidant constitute. In our present study we have examine different type of anti oxidant capacity like that total phenolic , DPPH radical , nitraxcite radical, hydroxyl radical and ABC radical in two solvent extract of ethanol and aqueous for different concentration like 0.1, 0.2, 0.5, 1.0 and 2.0 . In our result showed that maximum in 2.0 mg/ ml of leaves extract of ethanol and minimum in aqueous extract in 0.1 concentration for all antioxidant assay. In this result showed that highly effect in antioxidant levels in two solvent extract and varies concentration so I would be a good antioxidant property....
ABSTRACT\r\nNumerous diseases are associated with oxidative stress caused by free radicals. Current research is directed towards finding naturally-occurring antioxidants of the plant origin. The aim of the present study was to evaluate the in vitro antioxidant activities of Catharanthus roseus extract. 80% ethanol extract of Catharanthus roseus was studied in vitro for total antioxidant activity, for scavenging of hydroxyl radicals, nitric oxide and phenolic contents. Subsequent quantification showed the presence of 0.84% (m/m) phenolics (calculated as gallic acid) and 0.23% (m/m) flavonoids calculated as catechin equivalents per 100 g of fresh mass. The presence of phenolic compounds prompted us to evaluate its antioxidant activity. The present study provides evidence that the ethanol extract of Catharanthus roseus is a potential source of natural antioxidants....
Anxiety is one of the commonest psychiatric disorders and a large number of medicinal plants have been explored to treat this disorder. Anxiolytic-like action of methanolic extract of the seeds of Solanum torvum (ST) were studied in Swiss albino mice using elevated plus maze (EPM), light and dark transition apparatus (LDA), hole board apparatus (HBA) and marble burying test (MBT).In addition, the effect of Prazocin (62.5 µg/kg, i.p.), an alpha adrenoceptor antagonist; p-chlorophenylalanine (100 mg/kg, i.p.), an inhibitor of serotonin synthesis and haloperidol (50 µg/kg, i.p.), a D2 receptor antagonist on anxiolytic-like effect of ST in above four models were also studied. The effect of ST on PTZ (60 mg/kg, i.p) induced seizures was also studied. Methanolic extract of Solanum torvum (ST-10, 30 and 100 mg/kg) and its ethyl acetate fraction (EAF-10, 30 mg/kg) showed significant increase in open arm exploration, time spent in lit zone, number of head dips and significant decrease in no. of marbles buried in EPM, LDA, HBA and MBT respectively. Prazosin, p-chlorophenylalanine and haloperidol significantly reversed the ST induced anxiolytic effect in EPM, LDA, HBA and MBT. The extracts also protected animal against PTZ-induced seizures. These results suggest that anxiolytic like effect of ST facilitated the effects of adrenergic, serotonergic, dopaminergic and GABAminergic systems....
Dose fixing is the major troublesome parameter to elucidate for most of the oral antidiabetic agents even after preclinical toxicity studies. So our aim is to fix the dose that could be of maximum therapeutic efficacy with safer therapeutic margin of the drug used by means of incremental dose response study and area under the curve. Sprague dawley rats were made diabetic with Streptozotocin (45mg/kg/i.p.,). After 16 hours fasted condition the animals were subjected to OGTT with 1g/kg/p.o., of glucose before commencement of the treatment. Starting from the 30th min of glucose loading, the Sedimental Extract of Tinospora cordifolia (SETc) at incremental doses, from the minimum of 250mg/kg/p.o., to the maximum of 1000 mg/kg/p.o., (maximum dose selected from chronic toxicity studies) were administered to the respective groups and the AUC of the blood glucose concentration and the effective dose of the test drug were studied. The onset of action of all the doses of the SETc originates from the 60th min of the drug administration and showed the biological responses in a concentration dependant manner. The blood glucose concentration of the treated rats found to be inversely proportional to the concentration gradient. SETc at 1000 mg/kg showed its maximal dose response effect and marginal therapeutic regimen for its antidiabetic activity with lesser risk of hypoglycemic shock. From the IDF, AUC and EDF data’s obtained, it was evidenced that the application of this modified method as a valuable tool for finding safer marginal dose for some other antidiabetic agents also....
The world is facing an explosive increase in the incidence of diabetes mellitus and cost-effective combination therapies are needed. Pterocarpus marsupium and Metformin have been used for their antidiabetic effect for decades. The present study was aimed at finding novel combination of the synthetic antidiabetic, metformin and aqueous extract of the herbal antidiabetic agent, Pterocarpus marsupium and rationalization of dose thereof. Alloxan diabetic male albino Wistar rats weighing 150-200 g (N = 6) were fed various combinations of metformin and P. marsupium (240, 120, and 60 mg/kg of metformin along with 125, 250, and 500 mg/kg of P. marsupium respectively) for 10 consecutive days and tested for antidiabetic effect during acute and sub acute tests. Diabetic rats fed with all the combinations showed a decrease in fasting blood glucose (P<0.0001) vs. diabetic control, the group treated with the combination of metformin and P. marsupium 120 mg/kg and 250 mg/kg respectively found to be the best (P<0.0001).The combination including 240mg/kg of Metformin or 500 mg/kg of P. marsupium showed no mortality or abnormality. These data for the combination of metformin and P. marsupium are significant for antidiabetic activity and are adequate for phase 2 clinical trials to evaluate this novel combination as combination therapy in type 2 diabetes mellitus....
This study was performed to compare the aqueous & ethanolic extracts of the roots & stems of Nymphaea stellata Willd. (Nymphaeaceae) for diuretic activity on rats, to justify the traditional claim of this as per Indian Medicinal Plants (Kirtikar and Basu). Roots and stem were extracted by cold maceration process using demineralised water and ethanol as solvent. Diuretic activity was studied for volume of urine, excretion of sodium and potassium ions by flame photometry. The diuretic activity was assessed in doses 300, 500, 700 mg/kg/p.o. of both extracts separately using Furosemide (100 mg/kg/p.o.) as a standard. One way ANOVA test was used for statistical analysis. There was significant increase (p<0.0001) in urine volume and excretion of sodium and potassium ions at doses 500 & 700 mg/kg/ p.o. of aqueous extract as compared to control group and 300 mg/kg/p.o. of alcoholic extract as compared to control group. The present study revealed that the ethanolic extract was more effective and supports the traditional claim of Nymphaea stellata Willd. as a diuretic. The study concluded that urolithiatic activity can be further evaluated as it increases the excretion of Sodium and Potassium ions....
Bougainvillea glabra choisy (Nyctagaginaceae) or glory of garden has been reported as a traditional folklore medicine for treatment of various health problems in alone as well as in combination with other plants in some regions of western India. To investigate the effects of Bougainvillea glabra choisy (Nyctagaginaceae) leaves extract on wound healing parameters, we used excision, incision and dead space wound healing models in rats. Albino wistar rats were treated topically with ointment of aqueous extract of Bougainvillea leaves in excision model while in dead space & incision wound model animals were orally treated with aqueous extract of Bougainvillea leaves (200 mg/kg). after completion of 10 days wound contraction, wound breaking strength, granulation tissue weight were measured and found to increased significantly in extract treated groups as compared to control groups. These results suggest a beneficial role of Bougainvillea glabra choisy leaves aqueous extract in healing of wounds in experimental rats....
Traditional preparations from plant sources are widely used almost everywhere in the world to treat diabetes. Therefore, plant materials are considered to be the alternative sources for finding out new leads for hypoglycemic agents. The effects of the leaf of Urtica dioica, a traditional antidiabetic herb used in India and Bangladesh, on the insulinemic and chronic inflammatory status of type 1 diabetic model rats have been studied. The experiment for the chronic effects of the extract was performed with continuous feeding of the aqueous extract of the leaves of U. dioica at a dose of 1.25 g/10 ml water /kg body weight for 21 days. The rats were divided into four groups. Type 1 diabetes mellitus in rat was produced with a single intraperitoneal injection (i.p.) of streptozotocin to adult rats. Serum glucose was estimated by Glucose-Oxidase (GOD-PAP) method, serum insulin and CRP (as a marker for chronic inflammation) were measured by ELISA technique specific for rats. Results: There was a significant decrease (at day 7,p<0.01;at day 14 and 21, p=0.000) in the body weight of the U. dioica treated group. serum glucose levels was significantly (p<0.001) decreased by U. dioica in type 1 diabetic rats. Insulin secretion as expected were significantly (p<0.004) increase in extract fed group. The inflammatory marker CRP was also lowered by U. dioica aqueous extract. The hypoglycemic effect of U. dioica aqueous extract may have an association with improved insulinemic status linked to an anti-inflammatory effect of the plant extract on pancreatic β-cells....
Nigella sativa Linn has been used for centuries as a medicinal plant and possesses a number of pharmacological properties. In the present study the chloroform and methanol seed extracts of N.sativa were tested for their antibacterial activity against selected microbes at different concentrations of 300 µg, 600 µg and 900 µg respectively. Preliminary phytochemical screening of the seed extracts were also carried out. The results obtained for antibacterial study showed that the extracted fractions exhibited significant antibacterial activity against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Proteus mirabilis and exhibited no activity against Pseudomonas aeruginosa. Streptomycin was used as the standard reference drug in this study. The outcome of this study signifies the potentiality of N.sativa against bacterial pathogens....
Sunlight mainly comprises of ultraviolet radiation which is mainly classified into 3 types, by its wavelength : UVA, UVB & UVC. UV radiation is well known to exert a variety of deleterious effects on human skin. It is therefore desirable to promote a UV protective product that is completely herbal in origin & minimize the harmful side-effects of chemical sunscreens. The aim of this work was to study the UV absorption ability of various extracts of Garcinia indica Choisy. seeds as an anti-solar agent. Extracts were prepared using the following solvent mixtures:- Water : methanol (2:5), water : ethanol (1:1), Ethyl acetate and Petroleum Ether. The former two Hydroalcoholic extracts were prepared by maceration and the later two were prepared by Soxhlet method. Preliminary test on the extracts indicated the presence of flavonoids. UV spectroscopy showed that all the extracts, excluding Petroleum Ether extract, are UV broad spectrum extracts & can effectively absorb UV radiation in the range of 200- 400 nm. Very good absorbance of 0.9 and 0.7 in UVB region was shown by Hydromethanolic extract and Ethyl acetate extract respectively which might be due to flavonoids....
In the present study, Aqueous extract of Luffa echinata Roxb. (100, 200 & 300 mg/kg, P.O.) was used to screen the hepatoprotective activity. Hepatotoxicity was induced in experimental animals by administration of carbon tetrachloride (CCL4) (2.5 ml/kg, P.O.), silymarin (50 mg/kg, P.O.) was used as standard. Biochemical parameters like Aspartate transaminase (AST), Alanine transaminase (ALT) (Reitman & Frankel, 1957), Alkaline phosphatase (ALP), bilirubin and total protein were measured. Peroxidative hepatic damage in rat was studied by assessing parameters such as thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) in liver. The effect of co-administration of luffa echinata on above parameters and histopathological findings of liver in experimental animals was studied. CCL4 administration in rats elevated the levels of AST, ALT, ALP and bilirubin. Oral administration of aqueous extract significantly (P<0.001) prevented this increase. The activity of antioxidant enzyme in carbon tetrachloride CCL4-treated group was decreased and these enzyme level was significantly (P<0.001) increased in Luffa echinata treated groups. Histopathological studies revealed that the concurrent administration of CCL4 with the extract exhibited protection of the liver tissue, which further evidenced above results. The study confirmed the hepatoprotective activity of Luffa echinata, which may be attributed to its antioxidant activity....
The purpose of the present study is to investigate the neuropharmacological profile of Portulaca olaracea, by different methods like Elevated plus maze, Foot shock induced aggression, Morris water maze test. Elevated plus maze results indicates that the time spent in open arm were significantly increased in dose dependant manner in AEPO (1000mg/kg & 2000mg/kg) when compared to control group. The ratio of number of entries in open arm /total entries was reduced with increase in the dose. The results are comparable with that of standard. The ratio of number of entries in open arm / total entries vs drug treatment was observed in foot shock induced aggression. The AEPO (1000mg/kg & 2000mg/kg) showed a decrease in the number of fighting bouts with increase in the dose when compared to control supports of the anxiolytic activity was observed. In Morris water maze test the AEPO (1000mg/kg & 2000mg/kg) showed a decrease in the number of fighting bouts with increase in the dose when compared to control supports of the anxiolytic activity. The Elevated plus Maze Test is based on a premise where the exposure to an EPM evoked an approach –avoidance conflict that was considerably stronger than that evoked by the exposure to an enclosed arm .To further assess anxiolytic effect we used Open field test, Foot shock induced aggression. (AEPO- aqueous extract of Portulaca olaracea)...
The developing countries mostly rely on traditional medicines. This traditional medicine involves the use of different plant extracts or the bioactive constituents. This type of study provides the health application at affordable cost. This study such as ethnomedicine keenly represents one of the best avenues in searching new economic plants for medicine. In keeping this view in mind the present investigation is carried out in Polygonum barbatum linn. The results suggest that the phytochemical properties of the plant for curing various ailments....
Crataeva nurvala is a commonly used herbal drug against many diseases. The hepatoprotective activity of hydroalcoholic extract of dried powder of whole plant of Crataeva nurvala was investigated in carbon tetrachloride induced hepatotoxicity rat model. Hepatotoxicity was induced in Wistar rats by intraperitoneal injection of carbon tetrachloride. Different doses were tested to decide the dose related hepatoprotective efficacy of Crataeva nurvala (400 mg/kg, 600 mg/kg, 800 mg/kg bw). The Hepatoprotective effect of these extracts was evaluated by liver function biochemical parameters (i. e. total and direct bilirubin, cholesterol, alanine aminotransaminase, asparatate aminotransaminase and alkaline phosphatase activities).In extract-treated animals, the toxicity effect of carbon tetrachloride was controlled significantly by restoration of the levels of serum bilirubin, cholesterol and enzymes as compared to the normal and standard drug silymarin-treated groups. Therefore, the results of present study support the hepatoprotective effect of Crataeva nurvala...
Present study aims screening of anthelmintic activity of Boerhavia erecta Linn. Roots. Boerhavia erecta Linn roots were screened for in vitro anthelmintic activity. The powdered roots were extracted successively with petroleum ether, chloroform, ethyl acetate, methanol by soxhlation and chloroform water by maceration. Preliminary phytochemical screening of five extracts was carried out. Indian adult earthworms Pheretima posthuma were used for carring out activity. The time required to paralyse and death was measured and compared with that of standards like Albendazole and Piperazine citrate. Methanol extract showed excellent in vitro anthelmintic activity (paralysis time and death time as 3.25±0.21 min. (mean ± SD) and 19.03±0.25 min. respectively comparable to standard albendazole (2.20±0.25 min. as paralysis time and 16.53±0.41 min as death time) at 20 mg ml-1 concentration. Tannins present in Boerhavia erecta may be responsible for its anthelmintic activity....
Ruellia tuberosa Linn. is traditionally used in treatment of various ailments. As there is no detailed standardization work reported on various parts of Ruellia tuberosa Linn. Therefore, the present communication attempts to evaluate the physicochemical constant and preliminary phytochemical studies including the qualitative chemical test and qualitative thin layer chromatographic of stem, root and leaf of Ruellia tuberosa. The phytochemical analysis of the crude medicinal plant extract revealed the presence of saponin, alkaloids, triterpenoids, phenolic, sterols and flavanoid....
The aim of the study was to evaluate the anti inflammatory activity of methanolic extracts of Smithia sensitiva using Carrageenan induced paw edema method. Traditionally Smithia sensitiva is used in inflammation and in cancer. Our study objective is to evaluate scientifically whether it has anti-inflammatory activity. Qualitative chemical analysis of the extract of Smithia sensitiva revealed the presence of alkaloids, glucose and carbohydrates, steroids, tannins and flavanoids. Acute toxicity studies of the extracts showed that a dose up to 800 mg/ Kg body weight on albino mice was non toxic. The extract did not produce any characteristic behavioural changes. The maximum effect was produced at a dose of 400 mg/Kg at 180 minutes of administration and maximum inhibition was to the extent of 64.54%. In carrageenan induced paw edema model the extracts showed a significant anti-inflammatory activity (p<0.001) in a dose dependent manner....
The present paper deals with the phytochemical screening of therapeutic importance from Lawsonia ulba linn., an important medicinal plant. This study involves the preliminary screening, quantitative determination and the qualitative analysis of secondary metabolites of Lawsonia ulba linn.,. The generated data has provided the basis for its wide use as the therapeutant both in the traditional and folk medicines. The developing countries mostly rely on traditional medicines. This traditional medicine involves the use of different plant extracts or the bioactive constituents. This type of study provides the health application at affordable cost. This study such as ethnomedicine keenly represents one of the best avenues in searching new economic plants for medicine. In keeping this view in mind the present investigation is carried out in Lawsonia ulba linn. The results suggest that the phytochemical properties of the plant for curing various ailments....
Xanthium strumarium L. a medicinal plant commonly found as a weed, is widely distributed in North America, Brazil, China, Malaysia and hotter parts of India. The genus Xanthium includes 25 species; two species of Xanthium, X. indicum and X. strumarium have been reported in India. The herb is traditionally used mostly in treating several ailments. Various parts of Xanthium strumarium L. are found to possess useful medicinal properties such as antibacterial, antitumour, anticancer, antifungal, anti-inflammatory, antinociceptive, antititussive, hypoglycaemic, antimitotic, antitrypanosomal, antimalarial, diuretic, antioxidant, analgesic, repellent and insecticidal activities. This article provides a botanical description of the plant, its phytochemical constituents and pharmacological activities are reviewed. Most of the pharmacological effects can be explained by the constituents like sesquiterpene lactones, glycoside, phenols, polysterols present in all plant parts. Because of its multi-activity, so much attention is focused on the herb....
Seeds of Butea monosperma (Linn.) Kuntze has been used in Ayurveda and folklore medicine as contraceptive and anthelmintic. However many previous studies have shown its toxicological potential in different forms. The present study was carried out to evaluate repeated dose toxicity of seeds of Butea monosperma in the form of decoction. The test formulation was administered orally at the dose of 1620 mg/kg for 90 consecutive days. Parameters like ponderal changes, biochemical, haematological, bone marrow cytology and histopathology of vital organs were studied. The significant changes observed are increase in MCV, RDW percentage and decrease in MPV and PDW in haematological parameters, while significant increase in blood urea level in biochemical parameter. Histopathologically only change which can be considered as toxic is the marked decrease in the spermatogenesis in the testis. This study revealed that the seeds of Butea monosperma in the form of decoction have severe inhibiting effect on spermatogenesis....
Major interest of the scientific community towards explaining the use of plants to the health and other beneficial effects for the human race. In this regard, the concept of a foodstuff as natural medicines is very attractive. The citrus fruits are associated with reduced risk of cancer, cardiovascular antioxidant and neurodegenerative disorders. Consistent with this hypothesis is the fact that the incidence of these disorders is least in those populations where fruits and vegetables are the major elements in the human diet. Recent research has shown that most of the plant-derived compounds are promising nutraceuticals for control of various disorders especially cardiovascular, neurological and neoplastic disease. The richness of the polyphenolic contents in the citrus plants has made them popular choice for antioxidants, anticancer and cardiovascular health benefits. Polyphenols have been identified and known to possess a wide spectrum of pharmacological properties such as antioxidants, antiinflammatory, anti-microbial, anti-carcinogenic, anti-HIV, cardioprotective and neuroprotective influence. In view of their wide range of pharmacological and biological activities they seem to have great therapeutic potential and bioactive components for our foods....
The entire wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The stages of wound healing are inflammatory phase, proliferation phase, fibroblastic phase and maturation phase. The hydroalcoholic extract of Mimosa pudica Linn. (600 mg/kg/day) was evaluated for its wound healing activity in albino rats using excision and incision wound models. Extract treated animal’s exhibit significant reduction in wound area when compared to controls. The extract treated wounds are found to epithelize faster as compared to controls. Extremely significant (p<0.0001) increase in granuloma breaking strength (450±12.20) was observed. The betadin ointment 15 % was used as standard....
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